What it's for (Indications)
- Oxaprozin is used in the management of painful inflammatory conditions, including Rheumatoid arthritis (type of arthritis caused by autoimmune disorder), osteoarthritis (type of arthritis), gouty arthritis (arthritis due to uric acid build-up), ankylosing spondylitis (arthritis that affects the spine), juvenile rheumatoid arthritis (JRA), postoperative trauma, bursitis/tendinitis (inflammation of tendons and surrounding area between tendon and bone), sciatica (leg pain due to sciatic nerve), dysmenorrhea (painful menstruation), and dental pain and inflammation.
Dosage Information
| Type | Guideline |
|---|---|
| Standard | Carefully consider the potential benefits and risks of oxaprozin before use. Use the lowest effective dosage for the shortest duration consistent with individual patient treatment goals. Different dose strengths and formulations (e.g., capsules, tablets) of oral oxaprozin are not interchangeable. Typical adult dosages: For Osteoarthritis (OA): 1,200 mg given orally once a day. For Rheumatoid Arthritis (RA): 1,200 mg given orally once a day. Pediatric dosages for Juvenile Rheumatoid Arthritis (JRA): For patients 22 to 31 kg, 600 mg once daily; for patients 32 to 54 kg, 900 mg once daily; and for patients 55 kg or greater, 1,200 mg once daily. |
Safety & Warnings
Common Side Effects
- Common side effects include nausea, vomiting, diarrhea, constipation, dyspepsia, gastralgia (stomach pain), headaches, and skin rash.
- Clinically significant and serious adverse reactions may include Cardiovascular Thrombotic Events, GI Bleeding, Ulceration and Perforation, Hepatotoxicity, Hypertension, Heart Failure and Edema, Renal Toxicity and Hyperkalemia, Anaphylactic Reactions, Serious Skin Reactions, and Hematologic Toxicity.
Serious Warnings
- Black Box Warning: WARNING: RISK OF SERIOUS CARDIOVASCULAR AND GASTROINTESTINAL EVENTS. Nonsteroidal anti-inflammatory drugs (NSAIDs) cause an increased risk of serious cardiovascular thrombotic events, including myocardial infarction and stroke, which can be fatal. This risk may occur early in treatment and may increase with duration of use. NSAIDs also cause an increased risk of serious gastrointestinal adverse events including bleeding, ulceration, and perforation of the stomach or intestines, which can be fatal. These events can occur at any time during use and without warning symptoms. Elderly patients and patients with a prior history of peptic ulcer disease and/or GI bleeding are at greater risk for serious GI events. Oxaprozin is contraindicated for the treatment of peri-operative pain in the setting of coronary artery bypass graft (CABG) surgery.
- Oxaprozin must be used with caution by patients with renal impairment, hepatic (liver) problems, and gastro-intestinal problems.
- Research suggests this medicine is not safe for use during pregnancy and lactation.
- NSAIDs, including oxaprozin, are associated with risks of serious Cardiovascular Thrombotic Events, GI Bleeding, Ulceration and Perforation, Hepatotoxicity, Hypertension, Heart Failure and Edema, Renal Toxicity and Hyperkalemia, Anaphylactic Reactions, Serious Skin Reactions, and Hematologic Toxicity.
- Always use the lowest effective dosage for the shortest duration consistent with individual patient treatment goals.
How it Works (Mechanism of Action)
Oxaprozin has analgesic, anti-inflammatory, and antipyretic properties. Its mechanism of action, like that of other NSAIDs, is not completely understood but involves inhibition of cyclooxygenase (COX-1 and COX-2). Oxaprozin is a potent inhibitor of prostaglandin synthesis. Prostaglandins sensitize afferent nerves and potentiate pain, and are mediators of inflammation. By inhibiting prostaglandin synthesis, oxaprozin's mode of action may be due to a decrease of prostaglandins in peripheral tissues.