What it's for (Indications)
- Indicated for the treatment of episodes of depression associated with bipolar disorder type 1 and treatment-resistant depression in patients over 10 years old.
Dosage Information
| Type | Guideline |
|---|---|
| Standard | Adults: Initiate with 6 mg olanzapine/25 mg fluoxetine (6 mg/25 mg) once daily in the evening. The maximum dose is 12 mg/50 mg once daily. Pediatric patients (10 to 17 years old) with Bipolar Depression: Initiate with 3 mg/25 mg once daily. The maximum dose is 12 mg/50 mg. For patients predisposed to hypotensive reactions, hepatic impairment, or with potential for slowed metabolism, a starting dose of 3 mg/25 mg to 6 mg/25 mg is recommended, with cautious dose escalation. Administer once daily in the evening. |
Safety & Warnings
Common Side Effects
- Adverse reactions include: Suicidal Thoughts and Behaviors (in specific populations), Increased Mortality in Elderly Patients with Dementia-Related Psychosis, Neuroleptic Malignant Syndrome (NMS), Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS), Hyperglycemia, Dyslipidemia, Weight Gain, Serotonin Syndrome, Angle-Closure Glaucoma, Allergic Reactions and Rash, Activation of Mania/Hypomania, and Tardive Dyskinesia.
Serious Warnings
- Black Box Warning: WARNING: SUICIDAL THOUGHTS AND BEHAVIORS and INCREASED MORTALITY IN ELDERLY PATIENTS WITH DEMENTIA-RELATED PSYCHOSIS. Suicidal Thoughts and Behaviors — Antidepressants increased the risk of suicidal thoughts and behavior in children, adolescents, and young adults in short-term studies. These studies did not show an increase in the risk of suicidal thoughts and behavior with antidepressant use in patients over age 24; there was a reduction in risk with antidepressant use in patients aged 65 and ol
- The following warnings and precautions apply: Suicidal Thoughts and Behaviors (especially in children, adolescents, and young adults), Increased Mortality in Elderly Patients with Dementia-Related Psychosis, Neuroleptic Malignant Syndrome (NMS), Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS), Hyperglycemia, Dyslipidemia, Weight Gain, Serotonin Syndrome, Angle-Closure Glaucoma, Allergic Reactions and Rash, Activation of Mania/Hypomania, and Tardive Dyskinesia.
- Caution is advised in patients predisposed to hypotensive reactions, hepatic impairment, or with potential for slowed metabolism.
- Risk of QT interval prolongation.
How it Works (Mechanism of Action)
The mechanism of action of olanzapine and fluoxetine in the listed indications is unclear. However, the combined effect of olanzapine and fluoxetine at the monoaminergic neural systems (serotonin, norepinephrine, and dopamine) could be responsible for the pharmacological effect.
Commercial Brands (Alternatives)
No other brands found for this formula.